Does Omeprazole cause sexual side effects such as decreased libido or erectile dysfunction?

Omeprazole and sexual side effects: what we know Omeprazole, a proton pump inhibitor (PPI) used for acid-related conditions, has rare reports of sexual side effects most notably erectile dysfunction listed in official product labeling. ^[1] Erectile dysfunction appears in the “Urogenital” adverse reaction section across multiple omeprazole labels, indicating that it has been observed post‑marketing, although the frequency is not defined and is considered uncommon to rare. ^{[2] [3]}

What official labels report

• Erectile dysfunction is explicitly listed among post‑marketing urogenital adverse reactions for omeprazole (and certain omeprazole/sodium bicarbonate formulations). ^{[1] [2]}
• Other kidney and urinary findings (for example, interstitial nephritis, hematuria, proteinuria) are also noted, but these are separate from sexual function effects. ^{[3] [4]}
• Decreased libido is not consistently listed; however, erectile dysfunction specifically appears as an identified adverse reaction. ^{[5] [6]}

How common is it?

The labels document erectile dysfunction without giving a precise rate, which typically reflects rare, infrequent, or post‑marketing spontaneous reports rather than events seen commonly in clinical trials. ^[2] The absence of quantified incidence means the effect is likely uncommon; still, it is recognized enough to be included in the official safety information. ^[7]

Possible mechanisms (what’s plausible vs. proven)

• There is no definitive, proven mechanism linking PPIs to sexual dysfunction. ^[8]
• Theories sometimes raised include indirect effects (for example, nutrient changes over very long-term therapy or effects mediated by other comorbidities), but robust human data are lacking and most PPI safety reviews focus on other risks (drug interactions, fractures, hypomagnesemia). ^{[9] [10]}

Practical guidance if you notice symptoms

• Consider timing: if erectile symptoms began after starting omeprazole and improve after stopping or switching (under medical guidance), the medication could be a contributor. ^[2]
• Review other causes: high blood pressure, diabetes, depression, anxiety, alcohol, tobacco, and other medications (such as some antidepressants or blood pressure medicines) commonly affect sexual function and are statistically far more frequent causes than PPIs. ^[8]
• Discuss options with a clinician: alternatives may include dose reduction, on‑demand use where appropriate, switching to a different acid reducer, or addressing contributing factors; do not stop a prescribed PPI abruptly without medical advice, especially if treating conditions like severe GERD or ulcers. ^[9]

Summary table

• Listed adverse sexual effect on label: Erectile dysfunction. ^{[2] [3]}
• Decreased libido: Not consistently listed on omeprazole labels; evidence is limited. ^[5]
• Frequency: Not quantified; likely uncommon/rare based on post‑marketing nature of reports. ^[7]
• Mechanism: Unclear; major safety reviews emphasize other risks rather than sexual dysfunction. ^{[8] [9]}

Bottom line

• Erectile dysfunction has been reported with omeprazole and is included in official labeling, suggesting a possible, though uncommon, association. ^{[2] [3]}
• Decreased libido is not clearly established in labeling and appears less consistently reported. ^[5]
• If sexual side effects occur, it’s reasonable to consider omeprazole as one of several possible contributors and to discuss tailored management with a healthcare professional. ^[9]