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Persly Medical TeamPersly Medical Team
January 26, 20265 min read

Are Heart Palpitations Common in Prostate Cancer?

Key Takeaway:

Are Heart Palpitations a Common Symptom of Prostate Cancer?

Heart palpitations are generally not a common symptom of prostate cancer itself. They are more often related to non-cancer causes (like stress or caffeine), general medical conditions, or side effects of certain cancer treatments. Palpitations feel like a racing, fluttering, or pounding heartbeat and are usually harmless, but sometimes they can signal an irregular heart rhythm (arrhythmia) that needs medical attention. [1] Palpitations can still occur during cancer care because several therapies and health factors can affect the heart’s rhythm or strain the cardiovascular system. [2]


What Palpitations Feel Like

  • A fast, fluttering, or pounding heartbeat, sometimes with chest discomfort. [1]
  • They may come with lightheadedness or shortness of breath. Most episodes are benign, but persistent symptoms warrant a check. [1]

Are Palpitations Linked to Prostate Cancer?

The prostate cancer disease itself does not typically cause palpitations. [1] However, certain prostate cancer treatments can increase cardiovascular risks and occasionally affect heart rhythm. [3] [4] For example, androgen deprivation therapy (ADT) using gonadotropin-releasing hormone (GnRH) agonists (such as leuprolide) has been associated with a small increase in risks like heart attack, stroke, or sudden cardiac death, and can influence the heart’s electrical interval (QT/QTc), which relates to rhythm stability. [3] [4]


Common Causes of Palpitations During Cancer Care

  • Stress, anxiety, exercise, caffeine, and some over-the-counter medicines can trigger palpitations. [1]
  • Cancer treatments (chemotherapy, targeted therapy, immunotherapy, and radiation) can lead to heart rhythm changes (arrhythmias) among other cardiac effects. [2] These effects vary by drug and individual risk. [2]
  • Specific agents used in oncology have documented rates of atrial fibrillation or palpitations; for example, some targeted therapies and certain chemotherapies list palpitations among adverse effects. [5] [6] [7]
  • Electrolyte imbalances, anemia, infections, dehydration, thyroid issues, or drug interactions can also contribute to palpitations during treatment. Cardio-oncology programs screen and manage these risks proactively. [8]

Prostate Cancer Treatments and Heart Rhythm

  • GnRH agonists (e.g., leuprolide): Reported small increases in major cardiovascular events; monitoring for cardiovascular symptoms is advised, and QT/QTc effects are a consideration. [3] [4]
  • Chemotherapy or targeted therapies: Can cause arrhythmias and other cardiac toxicities depending on the agent; careful assessment of individual risk factors is recommended. [2] Patients with prior heart disease or arrhythmia risk may need closer monitoring. [9]

When to Seek Urgent Care

Get urgent medical help if palpitations are accompanied by chest pain, fainting, severe shortness of breath, confusion, or new/worsening fatigue these can signal serious heart issues. [10] Persistent or worsening palpitations during treatment should be reported promptly to your care team. [10]


How Palpitations Are Evaluated

  • History and exam: Triggers (caffeine, stress), timing with medications, associated symptoms. Doctors assess cardiovascular risk factors before and during cancer therapy. [8] [9]
  • Tests: Electrocardiogram (ECG), ambulatory monitors (Holter), blood work for electrolytes, hemoglobin (anemia), thyroid function; sometimes echocardiogram if structural heart disease is suspected. This targeted testing helps distinguish benign palpitations from arrhythmias needing treatment. [11]

Management Strategies

  • Address triggers: Limit caffeine and alcohol, stay hydrated, manage stress with relaxation techniques and sleep hygiene. These steps can reduce benign palpitations. [1]
  • Review medications: Your team may adjust cancer drugs or supportive meds if they’re contributing to rhythm issues or QT/QTc changes. Close monitoring is standard when higher-risk agents are used. [4] [2]
  • Treat underlying issues: Correct electrolyte imbalances, anemia, infections, or thyroid problems to stabilize heart rhythm. This often resolves palpitations without needing heart-specific drugs. [2]
  • Cardio-oncology collaboration: Specialists co-manage care to balance cancer control with heart safety, including preventive strategies and tailored monitoring. This approach is recommended for those with higher cardiovascular risk or concerning symptoms. [8] [9]
  • Medications for rhythm control: If an arrhythmia is confirmed (e.g., atrial fibrillation), treatments may include rate/rhythm control drugs or anticoagulation depending on risk; choices are individualized considering cancer therapy and potential interactions. Care teams weigh risks and benefits carefully. [2]

Practical Tips You Can Try

  • Track episodes: Note timing, activities, and any new medications or supplements when palpitations occur. Sharing this diary helps your clinicians pinpoint causes. [1]
  • Lifestyle support: Gentle exercise as tolerated, mindfulness or breathing exercises, and smoking cessation reduce overall cardiovascular risk, which is encouraged during cancer therapy. These measures support heart health throughout treatment. [9]
  • Ask about monitoring: If you’re starting ADT or other therapies with cardiac considerations, discuss baseline and follow-up ECGs or labs. Proactive monitoring can catch issues early. [4] [9]

Bottom Line

Palpitations aren’t a typical symptom of prostate cancer itself, but they can occur for many reasons during cancer care, including everyday triggers and certain treatments that affect the heart. [1] With appropriate evaluation and collaboration between oncology and cardiology, most palpitations can be safely managed while staying on track with cancer treatment. [2] [8] [9]


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Sources

  1. 1.^abcdefghHeart palpitations-Heart palpitations - Symptoms & causes - Mayo Clinic(mayoclinic.org)
  2. 2.^abcdefghChemotherapy side effects: A cause of heart disease?(mayoclinic.org)
  3. 3.^abcThese highlights do not include all the information needed to use LUTRATE DEPOT safely and effectively. See full prescribing information for LUTRATE DEPOT. LUTRATE® DEPOT (leuprolide acetate), for depot suspension Initial U.S. Approval: 2018(dailymed.nlm.nih.gov)
  4. 4.^abcdeLUPRON DEPOT- leuprolide acetate kit(dailymed.nlm.nih.gov)
  5. 5.^1851-Cardiac toxicity associated with antineoplastic agents(eviq.org.au)
  6. 6.^DailyMed - IMATINIB MESYLATE tablet(dailymed.nlm.nih.gov)
  7. 7.^PACLITAXEL PACLITAXEL- paclitaxel injection, solution(dailymed.nlm.nih.gov)
  8. 8.^abcdCardio-oncology — A marriage of cardiology & oncology(mayoclinic.org)
  9. 9.^abcdef1851-Cardiac toxicity associated with antineoplastic agents(eviq.org.au)
  10. 10.^abPatient information - Chronic/small lymphocytic leukaemia (CLL/SLL) - Chlorambucil and obinutuzumab(eviq.org.au)
  11. 11.^130739 | Stanford Health Care(stanfordhealthcare.org)

Important Notice: This information is provided for educational purposes only and is not intended to replace professional medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider before making any medical decisions.