Based on NIH | Is weight loss a side effect of sertraline?

Yes, weight loss can occur with sertraline, but it is not universal and tends to be modest; changes in appetite and weight (loss or gain) are recognized side effects, and decreased appetite with weight loss is specifically noted in children. ^{[1] [2]}

What sertraline can do to weight

• Appetite changes: Sertraline (an SSRI) can change appetite, which may lead to either weight loss or weight gain depending on the individual. ^[1]
• Weight change is variable: Official drug information lists “weight changes” among common side effects, without guaranteeing the direction, because people respond differently. ^[1]
• Children and teens: Decreased appetite and weight loss are specifically highlighted in pediatric use, and growth should be monitored during treatment. ^[2]

How common and how much?

• Short‑term effects: Many people experience gastrointestinal symptoms (like nausea or diarrhea) and reduced appetite in the early weeks, which can contribute to small, short‑term weight loss. ^[1]
• Long‑term patterns: Over time, the effect on weight is mixed; some may regain weight as side effects settle, while others continue to have reduced appetite. The official labeling uses the general term “weight changes” to reflect this variability. ^[1]

Why might sertraline affect weight?

• Serotonin and appetite: SSRIs increase serotonin signaling, which can suppress appetite in some individuals; this anorectic effect has been observed in experimental models with sertraline, showing reduced food intake and body weight independent of activity changes. ^[3]
• Individual factors: Baseline weight, diet, activity level, and how your body metabolizes the medicine all influence whether weight goes down, up, or stays stable. ^[1]

Practical guidance

• Monitor regularly: It can be helpful to track weight, appetite, and hydration especially during the first 1–2 months of treatment. ^[1]
• When to contact your clinician: If you notice persistent loss of appetite, unintentional ongoing weight loss, or any concerning symptoms, discuss them promptly; adjustments (dose changes, timing with food, or switching medications) can be considered. ^[1]
• Children and adolescents: Growth and weight should be followed closely, and caregivers should report notable appetite or weight changes. ^[2]

Quick summary

• Sertraline can be associated with weight loss, often through decreased appetite, particularly noted in younger users, but weight change varies and can also include weight gain. ^{[2] [1]}

Would you like help tracking your recent weight and appetite changes to decide whether they might be related to sertraline?