Based on NIH | Is constipation a side effect of lisinopril?

Yes constipation can occur with lisinopril, although it appears to be uncommon and is not among the most frequent side effects reported in large studies of this medicine. Official product information lists constipation as a possible gastrointestinal adverse reaction with lisinopril. ^[1] Major patient‑facing references emphasize more common effects like cough, dizziness, headache, nausea, and diarrhea, and do not list constipation as a common effect, suggesting it is less frequent. ^{[2] [3]}

What official information says

• FDA‑published labeling for lisinopril includes “constipation” within reported gastrointestinal adverse reactions, alongside vomiting, diarrhea, dyspepsia, and anorexia. This indicates constipation has been observed in patients taking lisinopril, even if at a low rate. ^[1]
• Consumer drug information for lisinopril typically lists cough, dizziness, headache, tiredness, nausea, and diarrhea as the more common side effects, and does not highlight constipation as common, implying it is less commonly reported. ^{[2] [3]}

How common is it?

Direct head‑to‑head frequency numbers for constipation with lisinopril are not prominently reported in summary patient materials, which focus on more frequent effects like cough and diarrhea. Older safety reviews of lisinopril describe headache, dizziness, cough, nausea, diarrhea, and fatigue among the most frequent complaints, while not highlighting constipation supporting that constipation is likely less common. ^{[4] [5]} That said, because constipation is listed in official labeling, it remains a recognized but infrequent possibility. ^[1]

Why might constipation happen?

There is no well‑defined, unique mechanism for lisinopril that would commonly cause constipation, unlike some other drug classes. When constipation occurs with lisinopril, it may be idiosyncratic or influenced by co‑factors such as diet, fluid intake, reduced activity, or other medications (for example, diuretics can contribute to dehydration, which can worsen constipation). ^[1]

When to seek help

• If you notice new or worsening constipation after starting lisinopril, it may be related, but other causes are also common, so it’s reasonable to first review hydration, fiber intake, and other medicines. ^[1]
• Seek medical advice promptly if constipation is severe, lasts more than a few days despite self‑care, or is accompanied by concerning symptoms (severe abdominal pain, vomiting, or inability to pass gas or stool), as these require evaluation. Your clinician may adjust therapy if a medication link is suspected. ^[1]

Practical tips to manage mild constipation

• Hydration: Aim for adequate fluids unless you’ve been told to restrict fluid for heart or kidney reasons. ^[1]
• Fiber: Increase dietary fiber gradually (fruits, vegetables, whole grains) and consider a fiber supplement if needed. Introduce fiber slowly to avoid gas and bloating. ^[1]
• Activity: Gentle daily movement can help regularity. Even short walks may help. ^[1]
• Over‑the‑counter options: If needed, bulk‑forming agents (psyllium), stool softeners (docusate), or osmotic laxatives (polyethylene glycol) can be used short‑term, but it’s a good idea to confirm these are appropriate with your clinician, especially if you have kidney issues or are on multiple medications. ^[1]

Bottom line

• Constipation is a recognized but uncommon side effect of lisinopril. ^[1]
• More common lisinopril side effects include cough, dizziness, headache, nausea, and diarrhea rather than constipation. ^{[2] [3]}
• If constipation starts after beginning lisinopril and does not improve with simple measures, discuss it with your clinician to consider other causes or whether a medication change is appropriate. ^[1]