Aspirin and Hair Loss: What We Know and How to Cope

Aspirin can be associated with hair loss, but this appears to be uncommon and is more clearly documented when aspirin is combined with extended‑release dipyridamole. ^{[1] [2]} In official product information for aspirin plus extended‑release dipyridamole, alopecia (hair loss) is listed among reported skin and appendage adverse effects. ^{[1] [2]} Stand‑alone consumer and professional monographs for plain aspirin commonly emphasize bleeding, ulcer risk, and allergic reactions, and do not routinely highlight hair loss as a typical side effect. ^{[3] [4] [5] [6]}

How strong is the evidence?

Regulatory labeling acknowledges alopecia with aspirin–dipyridamole, which suggests a possible link, although the overall frequency is not specified and seems low. ^{[1] [2]} By contrast, typical aspirin labels focus on bleeding and gastrointestinal risks and do not consistently list alopecia, indicating it is not a common adverse event with aspirin alone. ^{[3] [4] [5] [6]}

Other NSAIDs and related anti‑inflammatories more often note hair loss anecdotally than aspirin does, and some 5‑aminosalicylic drugs (related to salicylates) have reported mild hair loss in postmarketing experience. ^[7] This context supports that drug‑related hair shedding can occur within this broader drug family, even if it’s not a hallmark effect of plain aspirin. ^[7]

Possible mechanisms and patterns

When drug‑related hair loss occurs, it is typically a temporary shedding (telogen effluvium), which may improve after dose reduction or discontinuation, if appropriate. ^[1] While product labeling lists “alopecia” without mechanistic detail, the clinical course of many drug‑induced shedding events tends to be reversible once the trigger is removed or adjusted. ^[1]

When to seek medical advice

• If you notice new or worsening hair thinning after starting aspirin (especially combined with dipyridamole), discuss it with your clinician to review benefits vs. risks and other causes. ^[1]
• Sudden patchy hair loss (alopecia areata), scalp inflammation, or systemic symptoms should be evaluated promptly to rule out other conditions. ^[1]

Practical coping strategies

Gentle hair care can help minimize breakage and visible thinning while the underlying trigger is addressed. ^[8] Use mild, fragrance‑free shampoo and conditioner 2–4 times per week, rinse thoroughly, and pat the hair dry with a soft towel rather than vigorous rubbing. ^[8] Comb gently with a soft‑bristle brush, starting at the ends and working toward the scalp to reduce tugging. ^[8]

• Consider shorter hairstyles to make thinning less noticeable and reduce pull on strands. ^[8]
• Use cosmetic aids like hair powders or fibers to camouflage sparse areas if that feels helpful. ^[8]
• Protect the scalp from sun and cold with hats or scarves; choose gentle fabrics and a smooth pillowcase (satin or silk) to reduce friction. ^[9]
• If shedding is significant, exploring wig options and supportive programs can offer practical and emotional support. ^[10]

Medication review and adjustments

Do not stop aspirin on your own; instead, ask your clinician whether your dose, indication, and any combination therapies (like dipyridamole) should be adjusted based on your hair concerns and overall health needs. ^[1] If aspirin is being used for cardiovascular protection, changes should be individualized to avoid increasing clotting risk. ^[11]

Bottom line

Hair loss with aspirin appears rare and is more clearly recognized when aspirin is combined with extended‑release dipyridamole, but individual responses vary. ^{[1] [2]} Gentle hair care, scalp protection, and cosmetic strategies can ease the impact, and medical review can help confirm the cause and guide safe adjustments. ^{[8] [9]}