Based on NIH | Is anxiety a known side effect of amlodipine, and how common is it?

Yes anxiety is listed as a possible side effect of amlodipine (a calcium‑channel blocker), though it appears to be uncommon. Official product information includes “anxiety” among psychiatric adverse reactions reported with amlodipine. ^[1] Multiple amlodipine labels also list “anxiety” (often alongside insomnia, nervousness, abnormal dreams, and depersonalization). ^{[2] [3] [4] [5] [6]}

How common is it?

• Frequency category: The labels identify anxiety as an adverse event but generally do not provide a precise percentage, implying it is not among the most frequent events like swelling (edema), flushing, or dizziness. ^[1]
• Context from clinical trials: Pooled clinical trial reviews of amlodipine show a favorable overall safety profile, with most excess side effects vs. placebo driven by edema rather than mood or anxiety symptoms, suggesting such psychiatric effects are relatively infrequent. ^{[7] [8]}

What official sources say

• Psychiatric effects listed: Anxiety, insomnia, nervousness, depression, abnormal dreams, and depersonalization are documented on U.S. drug labels for amlodipine. ^[1] The same listings appear across multiple formulations (5 mg and 10 mg), reinforcing that anxiety has been observed post‑marketing or in trials. ^{[5] [6]}
• Other body systems affected: Labels also detail effects like dry mouth and increased sweating (autonomic), vision changes and tinnitus (special senses), and skin reactions; this broad pattern underscores that while anxiety can occur, it’s part of a wider but generally infrequent adverse‑event profile. ^{[2] [3] [4]}

Practical takeaways

• Relative rarity: While anxiety is recognized, available data and trial summaries suggest it is uncommon compared with typical amlodipine side effects such as ankle swelling. ^[7] Most people do not experience anxiety from amlodipine, but individual responses vary. ^[8]
• When to seek help: If new or worsening anxiety appears after starting or increasing amlodipine, it may be reasonable to discuss timing, dose, and alternatives with a clinician; other causes (stress, caffeine, other medicines) should also be considered.

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Quick reference table

Topic	What the evidence shows
Is anxiety listed on labels?	Yes “anxiety” is included among psychiatric adverse reactions. [1] [2] [3]
How often?	Not precisely quantified on labels; considered less common than edema and flushing. [7] [8]
Related psychiatric effects	Insomnia, nervousness, abnormal dreams, depersonalization, and depression also appear. [1] [4]
Overall safety profile	Generally favorable; most side effects are mild to moderate and linked to vasodilation (e.g., edema). [7] [8]

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Bottom line

Anxiety is a known but seemingly uncommon side effect of amlodipine according to official labeling and clinical experience. ^[1] Most users do not develop anxiety, and studies suggest the drug’s side‑effect burden is primarily edema rather than mood changes. ^{[7] [8]}