Based on NIH | Is it safe to drink energy drinks daily while taking omeprazole?

Daily energy drinks with omeprazole are not generally recommended because they often contain high caffeine and other stimulants that can worsen reflux symptoms, even though there is no known direct drug–drug interaction between omeprazole and caffeine. ^{[1] [2]} In other words, omeprazole does not meaningfully change how your body metabolizes caffeine, but caffeine can aggravate heartburn and reduce the benefit you get from omeprazole. ^{[3] [1]}

What the evidence suggests

• No direct interaction: Studies indicate omeprazole does not alter caffeine metabolism through the CYP1A2 pathway, so a pharmacokinetic interaction is unlikely. ^[3] Reviews of omeprazole interactions also report little to no effect on drugs handled by CYP1A (like caffeine/theophylline). ^{[4] [5]}
• Symptom-related concerns: Guidance for people taking omeprazole to control reflux commonly advises limiting or avoiding caffeine because it is a heartburn trigger and can relax the lower esophageal sphincter, worsening symptoms. ^{[1] [2]} Similar advice appears in consumer labeling for omeprazole products. ^{[6] [7]}

Why energy drinks can be problematic

• Caffeine load: Many energy drinks deliver 80–200+ mg of caffeine per serving, and cans may contain multiple servings, which can increase gastric acid–related symptoms despite acid suppression. Higher caffeine intake is more likely to trigger heartburn, palpitations, and sleep disturbance. ^{[1] [2]}
• Other stimulants and acids: Popular energy drinks often include additional stimulants (like taurine and herbal extracts) and are acidic or carbonated, both of which can further irritate the esophagus and promote reflux in some people. Even without a formal drug interaction, these properties can counteract symptom control. ^{[1] [2]}

Practical guidance if you still choose to drink them

• Limit caffeine intake: A cautious approach is to keep total daily caffeine to a moderate level (for many adults, ≤200 mg is gentler on reflux than higher amounts), and avoid multiple energy drinks per day. If heartburn worsens, consider reducing further or stopping. ^{[1] [2]}
• Timing matters: Take omeprazole before meals as directed, and try to avoid energy drinks on an empty stomach or late in the day, especially near bedtime, since late eating/drinking can worsen nighttime reflux. ^{[8] [9] [1]}
• Lifestyle habits that help: Eat smaller, slower meals; avoid lying down soon after eating; raise the head of the bed; and avoid tight clothing around the stomach; all of these can reduce reflux symptoms alongside medication. These steps can offset triggers from occasional caffeine. ^{[1] [2]}
• Watch for warning signs: If you notice persistent heartburn, chest discomfort, nighttime reflux, or new symptoms like tremor or rapid heartbeat, consider cutting back on energy drinks and discuss with your clinician, as you may need an adjustment in therapy or evaluation for other triggers. ^{[1] [2]}

Bottom line

• Safety perspective: There is no established harmful pharmacokinetic interaction between daily energy drinks (caffeine) and omeprazole. ^{[3] [4] [5]}
• Symptom control perspective: Daily energy drinks can reasonably be expected to aggravate reflux in many people, and product labeling for omeprazole advises limiting caffeine to improve heartburn control. For best results, limit or avoid energy drinks, especially if you notice more heartburn. ^{[1] [2] [6] [7]}