Based on NIH | Is it safe to eat shrimp after taking metformin?

You can safely eat shrimp after taking metformin. Metformin does not have known interactions with seafood, including shrimp, and it is generally recommended to be taken with meals to improve tolerance. ^{[1] [2]}

Quick facts

• Metformin works to lower blood sugar and is usually taken with food to reduce stomach side effects such as nausea or diarrhea. ^{[1] [3]}
• Food can slightly reduce and delay metformin absorption, which is expected and not harmful; taking it with meals is standard practice. ^{[2] [4]}
• Shrimp is a lean, high‑protein food with minimal carbohydrates, so it typically does not interfere with metformin’s effect on blood sugar. While official labels do not list seafood restrictions, they do advise caution with alcohol. ^{[5] [2]}

Why taking metformin with meals is recommended

Metformin commonly causes mild, temporary gastrointestinal symptoms (upset stomach, gas, diarrhea). Taking it with food can ease these effects, and this approach is part of routine use. ^[3] Food decreases peak levels and slows absorption (lower Cmax and AUC, delayed Tmax), but this does not reduce metformin’s clinical benefits; it improves tolerability for many people. ^{[2] [6]}

Shrimp specifically

There is no evidence that shrimp or shellfish cause harmful interactions with metformin. Shrimp is low in carbohydrates and calories and is a good protein source, which can support blood sugar control as part of a balanced meal. Metformin does not require avoiding particular foods, with the notable exception that heavy alcohol use should be avoided because it can raise the risk of lactic acidosis. ^[5] Lactic acidosis from metformin is rare and is mainly linked to significant kidney problems or other serious illnesses, not to normal foods. ^{[7] [8]}

Practical tips for eating shrimp on metformin

• Pair shrimp with fiber‑rich vegetables and whole grains to keep blood sugar steady and support digestive comfort. Taking metformin with this meal is appropriate. ^{[1] [2]}
• If you experience stomach upset on metformin, choose grilled or baked shrimp over fried options and avoid very spicy sauces until you know how you tolerate the medication. ^[3]
• Limit alcohol with meals; avoid binge drinking because it increases lactic acidosis risk on metformin. ^{[5] [7]}

When to be cautious

• If you have kidney disease or reduced kidney function, discuss metformin dosing and any symptoms (like unusual fatigue, muscle pain, or breathing trouble) with your clinician; these are general safety considerations and not specific to shrimp. ^[7]
• If you notice persistent gastrointestinal symptoms even when taking metformin with food, speak with your clinician about adjusting dose, using extended‑release formulations, or timing with meals. ^{[3] [4]}

Bottom line

Eating shrimp after taking metformin is considered safe, and taking metformin with meals (including shrimp) is often recommended to improve stomach comfort. ^{[1] [2]} Avoid heavy alcohol use, and be attentive to general safety guidance, especially if you have kidney issues. ^{[5] [7]}