Can I take losartan with milk, or does dairy interfere with its absorption or effectiveness?

You can take losartan with milk. Dairy does not meaningfully interfere with losartan’s absorption or overall effectiveness, and the medication can be taken with or without food. ^[1] A meal may slow how fast losartan is absorbed and lower the peak blood level slightly, but the total amount your body absorbs (overall exposure) changes only a little, which is unlikely to affect how well it works. ^{[2] [3]}

What the evidence shows

• Effect of food: Studies show that eating, especially a high‑fat meal, can slow absorption and reduce the peak concentration (Cmax) of losartan and its active metabolite; however, the overall exposure (AUC) changes only slightly (about a 10% decrease), which generally does not change clinical effect. ^{[2] [3]}
• Dosing flexibility: Official prescribing information states losartan combinations can be taken with or without food, reflecting that food including typical dairy intake does not require timing adjustments. ^[1]

Practical tips for taking losartan with dairy

• Consistency helps: While food has only a minor impact overall, it’s reasonable to take losartan the same way each day (with or without food) to keep levels steady. ^{[2] [3]}
• With milk or yogurt: It is acceptable to swallow your tablet with milk or have dairy around the time of your dose. ^[1]

Important related considerations

• Potassium caution: Some blood pressure drugs in this class can raise blood potassium; avoid potassium supplements or salt substitutes with potassium unless your clinician says otherwise. ^{[4] [5]}
• Other medicines: Certain drugs (for example, rifampin) can lower losartan levels, and others like NSAIDs may blunt blood pressure control, so it’s wise to review your medication list with your clinician. ^{[4] [6]}

Bottom line

• There is no specific dairy–losartan interaction to avoid. ^[1]
• Food, including dairy, may modestly slow and slightly reduce peak levels, but it does not meaningfully change overall absorption or effectiveness for most people. ^{[2] [3]}

Would you like guidance on timing your losartan dose with your current meals and other medicines?