Based on PubMed | Can I take fluoxetine with milk, or does milk interfere with its absorption?

You can take fluoxetine with milk. There is no evidence that milk or dairy products reduce fluoxetine’s absorption, and fluoxetine may be taken with or without food based on comfort and routine. ^[1] Fluoxetine is well absorbed in both the fed and fasted state, and food does not meaningfully change its overall absorption. ^[2]

What the evidence shows

• Food flexibility: Guidance for oral fluoxetine indicates it can be taken with or without food, which includes taking it alongside milk if that is easier on your stomach. ^[1]
• Absorption remains reliable: Clinical pharmacology data describe fluoxetine as well absorbed regardless of whether it’s taken when fed or fasting, supporting that routine foods like milk do not hinder its uptake. ^[2]

Why this is different from some antibiotics

• Not a calcium‑binding issue: Some medicines especially certain antibiotics like ciprofloxacin should not be taken simultaneously with dairy because calcium can bind the drug and reduce absorption. ^{[3] [4]} Fluoxetine is not in that category, so this specific dairy interaction does not apply. ^[2]

Practical tips for taking fluoxetine

• Choose a consistent routine: Taking fluoxetine at the same time each day helps you remember doses and maintain steady levels; taking it with breakfast and milk is reasonable if that suits you. ^[1]
• Manage stomach upset: If you experience nausea, taking fluoxetine with a small snack or milk can feel gentler, as food does not impair absorption. ^{[1] [2]}
• Watch for other interactions: While milk is fine, be mindful of medication interactions that can occur with fluoxetine (for example, certain serotonergic drugs); discuss all medicines and supplements with your clinician. ^{[5] [6]}

Summary

• Milk does not interfere with fluoxetine absorption, and you may take fluoxetine with milk if you prefer. ^{[1] [2]}
• Unlike some calcium‑sensitive drugs (e.g., ciprofloxacin), fluoxetine does not have a known dairy absorption problem. ^{[3] [4]}