Olive Oil and Aspirin: Is It Safe?

Short answer: Yes olive oil is generally safe to consume while taking aspirin. There is no recognized direct interaction between olive oil and aspirin, and eating olive oil as part of a meal does not meaningfully change aspirin’s antiplatelet effect. ^[1] Olive oil is a dietary fat and is not listed among foods or supplements known to raise bleeding risk when combined with aspirin. ^[2]

What We Know About Aspirin and Food

• High‑fat meals do not significantly alter aspirin’s effect on platelets. When aspirin was taken with a high‑fat meal, there was no meaningful change in overall exposure (AUC), and a reduced peak level (Cmax) was not considered clinically relevant because platelet cyclo‑oxygenase inhibition remained similar. ^[1]
• Aspirin’s main food‑related concerns involve bleeding risk increases from certain supplements or alcohol not typical dietary fats like olive oil. Several herbal supplements (for example, ginkgo, fish oil/omega‑3s) and alcohol can increase bleeding risk when combined with daily aspirin. ^[2]

What Can Interact With Aspirin

• NSAIDs (like ibuprofen and naproxen) can increase bleeding and may interfere with aspirin’s antiplatelet action if taken regularly. These medicines thin the blood and raise bleeding risk when combined with aspirin. ^[3]
• Other drugs and some supplements may also increase bleeding risk when taken with aspirin. Your healthcare team may need to carefully manage combinations with prescription blood thinners and certain other medicines. ^{[4] [5]}
• Alcohol can add stomach bleeding risk with aspirin. Moderation is advised if you drink alcohol while on daily aspirin therapy. ^[2]

Practical Tips

• Enjoy olive oil as part of a balanced diet. Olive oil does not have a known direct interaction with aspirin and is safe to consume with meals. ^[1]
• Be cautious with add‑on supplements. If you also take fish oil (omega‑3), ginkgo, or other herbal products, discuss bleeding risk with your clinician. ^[2]
• Use safer pain relief options if needed. If you require pain or fever relief while on aspirin, acetaminophen may be a safer choice than ibuprofen or naproxen to avoid interference and added bleeding risk. ^[6]
• Keep your care team informed. Always share all medicines and supplements you take so they can help prevent interactions and manage bleeding risk. ^{[7] [8]}

Bottom Line

Olive oil does not have a known interaction with aspirin and is generally safe to eat while you take it. Evidence shows high‑fat meals do not meaningfully change aspirin’s antiplatelet effect, and olive oil is not among foods or supplements that raise bleeding risk with aspirin. ^{[1] [2]}