Based on FDA | Is it safe to eat grapefruit or drink grapefruit juice while taking amlodipine?

Yes based on official prescribing information, grapefruit and grapefruit juice do not meaningfully affect amlodipine levels, and they are generally considered safe to consume with amlodipine. ^{[1] [2]}

Key Takeaway

• Official U.S. labeling notes that co‑administration of about 240 mL (1 cup) of grapefruit juice with a 10 mg dose of amlodipine showed no significant change in how the body handles amlodipine. ^{[1] [2]}
• Some consumer and professional monographs further state you can take amlodipine with most drinks, including grapefruit juice. ^[3]

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Why grapefruit is a concern with some drugs

Grapefruit products can inhibit an intestinal enzyme (CYP3A4) that metabolizes many medications, which can raise drug levels and side‑effect risk for certain drugs like nifedipine and some statins. ^{[4] [5]} However, amlodipine appears less affected by grapefruit than several other calcium channel blockers. ^{[1] [2]}

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What official sources say about amlodipine and grapefruit

• In healthy volunteers, 240 mL grapefruit juice taken with a single 10 mg dose of amlodipine showed no significant effect on amlodipine exposure (how much drug gets into the bloodstream). ^{[1] [2]}
• Combination products that include amlodipine report the same finding: 240 mL grapefruit juice had no significant pharmacokinetic impact on amlodipine. ^{[6] [7]}
• Some labels and consumer information explicitly note that amlodipine may be taken with grapefruit juice. ^{[3] [8]}

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Practical guidance for everyday use

• Moderate consumption of grapefruit or grapefruit juice is generally acceptable while taking amlodipine, as it has not been shown to significantly change amlodipine levels. ^{[1] [2]}
• If you also take other medications that are sensitive to grapefruit (for example, certain statins or other calcium channel blockers like nifedipine), you may still need to limit grapefruit because of those drugs, not because of amlodipine. ^{[4] [5]}
• If you notice dizziness, lightheadedness, flushing, or ankle swelling after unusually large amounts of grapefruit juice, consider reducing grapefruit intake and discuss with your clinician, especially if you are on multiple heart medicines. These symptoms can occur with amlodipine itself and are not typically driven by grapefruit, but paying attention to patterns is reasonable. ^{[1] [2]}

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At-a-glance comparison

Item	Amlodipine + Grapefruit	Nifedipine + Grapefruit
Effect on drug levels	No significant change with 240 mL grapefruit juice in volunteers. [1] [2]	Can increase levels and drop blood pressure more rapidly in some cases. [9]
General advice	Typically safe with moderate grapefruit intake. [3] [1] [2]	Prefer avoiding grapefruit products to reduce interaction risk. [4]

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Bottom line

• For amlodipine, grapefruit and grapefruit juice have not shown a significant interaction in clinical pharmacokinetic studies, and moderate intake is generally acceptable. ^{[1] [2]}
• Always consider your full medication list, because other drugs not amlodipine may still interact with grapefruit. ^{[4] [5]}