Based on FDA | Is it safe to take amlodipine with fish oil supplements, or are there any known interactions?

Most people can take amlodipine and fish oil together without problems, and there is no direct, well‑documented drug–drug interaction between the two. ^{[1] [2]} However, fish oil can slightly lower blood pressure and can have a mild blood‑thinning effect, so combining it with a blood pressure medicine like amlodipine may modestly add to blood pressure lowering and could theoretically increase bleeding tendency in some situations. ^{[3] [4]}

What the evidence suggests

• Amlodipine’s official prescribing information lists interactions mainly with CYP3A4 inhibitors/inducers and certain statins (notably simvastatin), and it notes safe co‑administration with many common drugs; fish oil is not listed as a contraindicated or interacting agent. ^{[1] [5]}
• Omega‑3 fatty acids (EPA/DHA) from fish oil have cardiovascular benefits and generally do not adversely interact with antihypertensive drugs; any blood pressure reduction from fish oil is usually small. ^{[2] [6]}
• Authoritative guidance notes fish oil may slightly lower blood pressure, so effects may add up with blood pressure medications. ^{[3] [4]}
• Fish oil can have antiplatelet effects, meaning it can increase bleeding risk when combined with other agents that affect clotting. ^[3]

Practical safety tips

• If you already take amlodipine and start fish oil, consider checking home blood pressure more often for the first 1–2 weeks to ensure it does not drop too low. ^{[3] [4]}
• Watch for symptoms of low blood pressure such as dizziness, light‑headedness, or fainting, and report persistent issues to your clinician. ^{[3] [4]}
• If you also take blood thinners or antiplatelet agents (for example, warfarin, clopidogrel, aspirin), discuss fish oil dosing with your clinician because of additive bleeding risk. ^[3]
• Standard supplement doses (often 1 gram/day of combined EPA+DHA) are commonly well tolerated; very high doses may increase bleeding risk, especially around surgery your care team may advise holding fish oil before procedures. ^[3]

Who should be more cautious

• People with a history of easy bruising, active bleeding conditions, or those scheduled for surgery may need individualized guidance on fish oil dosing or temporary discontinuation. ^[3]
• Individuals on multiple blood pressure medicines may experience a slightly greater cumulative effect on blood pressure when adding fish oil. ^{[3] [4]}

Bottom line

• There is no known direct pharmacokinetic interaction between amlodipine and fish oil, and they are generally considered safe to take together. ^{[1] [2]}
• Because fish oil can modestly lower blood pressure and has antiplatelet effects, a “monitor and adjust if needed” approach is reasonable, especially if you use other blood pressure or blood‑thinning medications. ^{[3] [4]}

Would you like to share your current amlodipine dose and fish oil amount so I can suggest a monitoring plan that fits you?